Monitor Structural Variants and Genomic Stability with dGH SCREEN™ Assays
dGH SCREEN™ is a single-cell assay designed to monitor structural variants throughout the genome. The assay uses patented directional Genomic Hybridization™ (dGH™) technology combined with multiplex fluorescence labeling to track and localize a wide variety of chromosomal rearrangements with a limit of detection as low as 5kb.
Overview of dGH SCREEN™ Assay Services:
- Detection of exchange events including reciprocal, balanced and allelic translocations; orientation events like inversions and sister chromatid exchanges;
- Chromosomal gain and loss events including sister chromatid fusions, dicentrics/acentrics, fragmentation/chromothrypsis, polypoidy and aneuploidy.
- Cellular engineering outcomes: genome-wide, cell-by-cell and chromosome-by-chromosome assessment of structure, pre- and post-modification;
- Orthogonal data for sequencing: genome-wide, confirmatory data regarding rearrangements predicted with long read and other NGS analyses;
- Structural integrity QC: a straightforward yardstick by which to measure the relative stability of cell lines, or to screen and compare candidate cell lines, based on total genomic structural variation metrics;
- Genomic stability assessment: Track persistence of variants over time, passages and process variable changes;
- Variant discovery: discover previously unknown mutations by de novo assessment of single cells from patient sub-types.
dGH SCREEN™ analysis produces the kinds of rearrangement data needed to create stability and structural variance profiles for complex, heterogeneous cell populations.
This makes dGH SCREEN™ one of the most comprehensive and robust karyographic assays available.
Ordering Information
SKU |
PRODUCTS |
LIST PRICE |
|---|---|---|
| SCR-001 | SCREEN Adherent/Suspension Culture Development: Thaw, recovery, and harvest optimization | $1,500.00 |
| SCR-002 | SCREEN Assay Execution and Analysis: Imaging and scoring for 50 spreads/sample | $5,775.00 |
| SCR-003 | SCREEN Assay Execution and Analysis: Imaging and scoring for 20 spreads/sample | $3,465.00 |
| SCR-004 | SCREEN Assay Execution and Analysis: Imaging and scoring for 100 spreads/sample | $10,395.00 |
| SCR-005 | SCREEN T-Cell Culture Development: Thaw, recovery, and harvest optimization | $1,625.00 |
| SCR-006 | SCREEN IPSC Cell Culture Development: Thaw, recovery, and harvest optimization | $1,750.00 |
| SCR-007 | SCREEN Whole Blood Culture Development: Thaw, recovery, and harvest optimization | $1,250.00 |
| SCR-008 | SCREEN Metaphase Adherent/Suspension Prep and Harvest | $1,500.00 |
| SCR-009 | SCREEN T Cells Metaphase Prep and Harvest | $1,625.00 |
| SCR-010 | SCREEN™ IPSC Metaphase Prep and Harvest | $1,750.00 |
| SCR-011 | SCREEN™ Whole Blood Metaphase Prep and Harvest | $1,250.00 |
| SCR-012 | SCREEN™ Chr1p E-Banding mini-Analysis on 100 existing cells | $,1050.00 |
| SCR-013 | SCREEN™ NK Cells Metaphase Prep and Harvest | $1,625.00 |
| SCR-014 | SCREEN™ NK Cell Culture Development: Thaw, recovery, and harvest optimization | $1,625.00 |