dGH SCREEN™ Assay Services
Our single cell assay, dGH SCREEN™ is designed to monitor structural variants throughout the genome. By utilizing patented directional Genomic Hybridization™ technology combined with multiplex fluorescence labeling, researchers can track and localize a wide variety of chromosomal rearrangements with a limit of detection as low as 5kb. By utilizing our chromosome paints and creating a 5 color assay, you will receive high resolution analysis of DNA repair activity by monitoring hallmarks of genomic instability, including sister chromatid changes.
Overview of dGH SCREEN™ Assay Services:
- Detection of exchange events including reciprocal, balanced and allelic translocations;
- Orientation events like inversions and sister chromatid exchanges;
- Chromosomal Gain & Loss Events including sister chromatid fusions, dicentrics/acentrics, fragmentation/chromothrypsis, polypoidy and aneuploidy;
- Cellular engineering outcomes: genome-wide, cell-by-cell and chromosome-by-chromosome assessment of structure, pre- and post-modification
- Orthogonal data for sequencing: genome-wide, confirmatory data regarding rearrangements predicted with long read and other NGS analyses;
- Structural integrity QC: a straightforward yardstick by which to measure the relative stability of cell lines, or to screen and compare candidate cell lines, based on total genomic structural variation metrics;
- Genomic Stability Assessment: Track persistence of variants over time, passages, process variable changes, etc.
- Variant discovery: discover previously unknown mutations by de novo assessment of single cells from patient sub-types;
dGH SCREEN™ analysis produces vast amounts of rearrangement data which can be used to create stability and structural variance profiles for complex and heterogeneous cell populations, making dGH SCREEN™ one of the most comprehensive and robust karyographic assays available.
Ordering Information
SKU |
PRODUCTS |
LIST PRICE |
|---|---|---|
| SCR-001 | SCREEN Adherent/Suspension Culture Development: Thaw, recovery, and harvest optimization | $1,200.00 |
| SCR-002 | SCREEN Assay Execution and Analysis: Imaging and scoring for 50 spreads/sample | $5,500.00 |
| SCR-003 | SCREEN Assay Execution and Analysis: Imaging and scoring for 20 spreads/sample | $3,300.00 |
| SCR-004 | SCREEN Assay Execution and Analysis: Imaging and scoring for 100 spreads/sample | $9,900.00 |
| SCR-005 | SCREEN T-Cell Culture Development: Thaw, recovery, and harvest optimization | $1,300.00 |
| SCR-006 | SCREEN IPSC Cell Culture Development: Thaw, recovery, and harvest optimization | $1,400.00 |
| SCR-007 | SCREEN Whole Blood Culture Development: Thaw, recovery, and harvest optimization | $1,000.00 |
| SCR-008 | SCREEN Adherent/Suspension Metaphase Prep and Harvest | $1,200.00 |
| SCR-009 | SCREEN T Cells Metaphase Prep and Harvest | $1,300.00 |
| SCR-010 | SCREEN IPSC Metaphase Prep and Harvest | $1,400.00 |
| SCR-011 | SCREEN Whole Blood Metaphase Prep and Harvest | $1,000.00 |