dGH SCREEN™ Targeted Assay Services
dGH SCREEN™ High Resolution Karyotyping

Monitor Structural Variants and Genomic Stability within 5kb.

dGH SCREEN™ analysis produces the kinds of rearrangement data needed to create stability and structural variance profiles for complex, heterogeneous cell populations, creating a comprehensive and robust karyograph.

Key benefits of dGH SCREEN™ assays:

  • Detection of exchange events including reciprocal, balanced and allelic translocations; orientation events like inversions and sister chromatid exchanges.
  • Chromosomal gain and loss events including sister chromatid fusions, dicentrics/acentrics, fragmentation/chromothrypsis, polypoidy and aneuploidy.
  • Cellular engineering outcomes: genome-wide, cell-by-cell and chromosome-by-chromosome assessment of structure, pre- and post-modification;
  • Orthogonal data for sequencing: genome-wide, confirmatory data regarding rearrangements predicted with long read and other NGS analyses;
  • Structural integrity QC: a straightforward yardstick by which to measure the relative stability of cell lines, or to screen and compare candidate cell lines, based on total genomic structural variation metrics; 
  • Genomic stability assessment: Track persistence of variants over time, passages and process variable changes;
  • Variant discovery: discover previously unknown mutations by de novo assessment of single cells from patient sub-types. 
  • Confirm and further characterize large structural rearrangements found by G-Banding.

Figure Above: dGH SCREEN™ 5 color whole genome karyotype

Ordering Information

Catalog Number
Services
Cost
SCR-001 SCREEN Adherent/Suspension Culture Development: Thaw, recovery, and harvest optimization $1,500.00
SCR-002 SCREEN Assay Execution and Analysis: Imaging and scoring for 50 spreads/sample $5,775.00
SCR-003 SCREEN Assay Execution and Analysis: Imaging and scoring for 20 spreads/sample $3,465.00
SCR-004 SCREEN Assay Execution and Analysis: Imaging and scoring for 100 spreads/sample $10,395.00
SCR-005 SCREEN T-Cell Culture Development: Thaw, recovery, and harvest optimization $1,625.00
SCR-006 SCREEN IPSC Cell Culture Development: Thaw, recovery, and harvest optimization $1,750.00
SCR-007 SCREEN Whole Blood Culture Development: Thaw, recovery, and harvest optimization $1,250.00
SCR-008 SCREEN Metaphase Adherent/Suspension Prep and Harvest $1,500.00
SCR-009 SCREEN T Cells Metaphase Prep and Harvest $1,625.00
SCR-010 SCREEN™ IPSC Metaphase Prep and Harvest $1,750.00
SCR-011 SCREEN™ Whole Blood Metaphase Prep and Harvest $1,250.00
SCR-012 SCREEN™ Chr1p E-Banding mini-Analysis on 100 existing cells $,1050.00
SCR-013 SCREEN™ NK Cells Metaphase Prep and Harvest $1,625.00
SCR-014 SCREEN™ NK Cell Culture Development: Thaw, recovery, and harvest optimization $1,625.00