dGH SCREEN utilizes KromaTiD’s single stranded, synthetic probes to cover every available sequence in the genome for the ultimate unbiased assessment of potentially causative structural variants. By spanning entire chromosomes, dGH SCREEN enables researchers to directly visualize structural rearrangements anywhere in the genome, making it possible to discover previously unseen or unsuspected rearrangements without knowing where to look in the first place.
Through our work with the Undiagnosed Diseases Consortium and others within industry and academia, we have demonstrated the value of utilizing SCREEN as a discovery tool in patients with undiagnosed diseases. Because of KromaTiD’s proprietary cell preparation methods and probe design, dGH SCREEN has detected a previously unknown inversion in both an undiagnosed disease patient and one of their family members.
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