Direct, Definitive Genomics

single-cell innovative solutions for the discovery detection and quantification of genomic structural variations for gene and cell therapy scientists
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Products + Services

superior mutation detection

Cell Line Processing

Optimization

Quality Control

Examines edits one cell at a time

Tracks complex rearrangements with 2kb resolution

Detects structural variations in off-target effects of CRISPR/Cas9

Unidirectional dGH probes

Unbiased, whole-genome assessment of all structural rearrangements

10x resoltution over G-banding

synthetic oligonucleotide-based FISH assay

2-3k base pairs

3x Signal/Resolution 6x the signal-to-noise ratio 50% lower background

Traditional G-banding and karyotyping analysis

Gold standard structural rearrangement detection

Applications

cell and gene therapies, gene editing, cancer studies,
radiation biodosimetry

kromatid gene editing

Cell and Gene Therapy

Monitoring Cellular Engineering Outcomes

On/Off Target Effects

Orthogonal Data for Sequencing

Variant Discovery

Genomic Stability Assessment

Oncology

Single-Cell Analysis

Complex Variation

Fusion Genes

Kromatid radiation biodosimetry

Radiation Biodosimetry

directional Genome Hybridization (dGH)

Structural Rearrangements

Inversions

Translocations

KromaTiD News

Essential, unique tools for discovery, detection and quantification of genomic structural variations