Ultra High-resolution Pinpoint FISH Probes
KromaTiD’s Pinpoint FISH probes can also be used for detecting genetic abnormalities associated with cancer. Monitor structural rearrangements and track genomic loci as small as 10kb. While BAC and many other FISH probes have limits of detection around 100kb; Pinpoint FISH probes can detect smaller targets than BAC FISH probes and can be used in interphase or metaphase cells with a variety of color and design options available to help you get the data you need. Pinpoint FISH™ probes allow researchers to expand beyond the capabilities of conventional FISH probes to design ultra-high specificity tests without the need for Cot-1 DNA blocking.
Pinpoint FISH™ DNA probes can be used for any FISH application including:
- Centromere enumeration
- Sub-telomere enumeration
- Oncology gene target enumeration
- Structural rearrangement detection
KromaTiD can produce custom Pinpoint FISH™ probes for any target in any sequenced mammalian genomes (e.g., mouse).
Cover Every Available Sequence with dGH SCREEN™
dGH SCREEN utilizes KromaTiD’s single stranded, synthetic probes to cover every available sequence in the genome for the ultimate unbiased assessment of potentially oncogenic rearrangements. By spanning entire chromosomes, dGH SCREEN enables researchers to directly visualize structural rearrangements anywhere in the genome, making it possible to monitor stability and other genomic hallmarks of cancer without needing to know where to look in the first place.
Used by itself or combined with dGH in-Site, SCREEN provides unbiased, whole genome data on translocations, inversions, copy number variants and other complex rearrangements in a single assay.
Examine Patient Samples One Cell at a Time with
dGH in-Site gives researchers the ability to directly visualize and characterize rearrangements at targeted loci in genetic disease patient samples. Using synthetic oligo probes and repeat-free bioinformatic design, dGH in-Site is capable of tracking translocations, inversions, copy number variants, viral integrations and other complex rearrangements with an approximate 2kb resolution.
In-site allows researchers to examine patient samples one cell at a time without having to worry about PCR biases or misrepresentative sequencing averages from heterogeneous cell populations.
Instead, as an orthogonal and complementary technique, in-Site allows you to gather the most comprehensive data available in order to help provide as many answers as possible for patients of rare or undiagnosed genetic diseases.
Learn More About dGH in-Site →