Oncology Services

Ultra High-resolution Pinpoint FISH Probes

kromatid pinpoint fishKromaTiD’s Pinpoint FISH probes can also be used for ultra high-resolution FISH assays, by modifying hybridization conditions and eliminating daughter strand degradation. In cells that rarely divide or are non-dividing, Pinpoint FISH can be used to monitor structural rearrangements with the same resolution and applicability as dGH in-Site.

As opposed to BAC and many other FISH probes with limits of detection around 10kb, Pinpoint FISH is capable of tracking genomic loci as small as 2kb. Pinpoint FISH probes can be used in interphase or metaphase cells with a variety of color and design options available to help you get the data you need.

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dGH SCREEN™

Cover Every Available Sequence with dGH SCREEN

Kromatid dGH SCREENdGH SCREEN utilizes KromaTiD’s single stranded, synthetic probes to cover every available sequence in the genome for the ultimate unbiased assessment of potentially oncogenic rearrangements. By spanning entire chromosomes, dGH SCREEN enables researchers to directly visualize structural rearrangements anywhere in the genome, making it possible to monitor stability and other genomic hallmarks of cancer without needing to know where to look in the first place.

Used by itself or combined with dGH in-Site, SCREEN provides unbiased, whole genome data on translocations, inversions, copy number variants and other complex rearrangements in a single assay.

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dGH in-Site™

Examine Patient Samples One Cell at a Time with dGH in-Site

Kromatid dGH In-sitedGH in-Site gives researchers the ability to directly visualize and characterize rearrangements at targeted loci in genetic disease patient samples. Using synthetic oligo probes and repeat-free bioinformatic design, dGH in-Site is capable of tracking translocations, inversions, copy number variants, viral integrations and other complex rearrangements with an approximate 2kb resolution.

In-site allows researchers to examine patient samples one cell at a time without having to worry about PCR biases or misrepresentative sequencing averages from heterogeneous cell populations.

Instead, as an orthogonal and complementary technique, in-Site allows you to gather the most comprehensive data available in order to help provide as many answers as possible for patients of rare or undiagnosed genetic diseases.

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PRODUCTS + SERVICES

dGH SCREEN
dGH in-Site
Pinpoint FISH
G-Banding