Pinpoint FISH™ is a synthetic oligonucleotide based FISH assay designed to provide the highest resolution, lowest background, and lowest limit of detection available. By modifying the hybridization conditions and eliminating strand degradation steps, Pinpoint FISH™ allows researchers to expand beyond the capabilities of conventional FISH probes to detect smaller targets and design ultra-high specificity tests.
Our technology provides scientists, a robust and bright signal with low background noise, and no Cot-1 DNA blocking. Pinpoint FISH™ probes can be designed for a wider range of targets and target sizes Pinpoint FISH™ assays can easily detect mutations with variable breakpoints free of repetitive sequences. Pinpoint FISH™ provides robust performance and consistent hybridization quality.
A lymphoblast cell line was fixed and hybridized labeled with a KromaTiD Pinpoint FISH breakapart probe (yellow)