Pinpoint FISH™ is a synthetic oligonucleotide based FISH assay designed to provide the highest resolution, lowest background, and lowest limit of detection available. By modifying the hybridization conditions and eliminating strand degradation steps, Pinpoint FISH™ allows researchers to expand beyond the capabilities of conventional FISH probes to detect smaller targets and design ultra-high specificity tests.
Our technology is fully compatible with your standard FISH equipment/conditions and BAC probes, and works with your established samples, workflow, and imaging system. Providing 3x the relative signal; 3x the resolution and 6x the signal-to-noise ratio; 50% lower background. Pinpoint probes can be designed for a wider range of targets and target sizes Pinpoint FISH assays can easily detect mutations with variable breakpoints free of repetitive sequences, and no blocking required. Pinpoint FISH PPF™ provides Robust performance and consistent hybridization quality.
A lymphoblast cell line (GM15510) was fixative and probed with KromaTid p53 probe yellow.