KromaTiD offers a full range of dGH and Pinpoint FISH products and services, ranging from targeted rearrangement assays to unbiased screening of the entire genome.
In addition to our standard probes and services, we specialize in quickly and efficiently designing custom assays to your specifications. You provide the samples—culture, tissue or blood—we design, validate, and execute the assays, providing you with comprehensive reporting and analysis every step of the way.
KromaTiD’s proprietary platform, directional Genome Hybridization (dGHTM), provides researchers and scientists:
- Rapid assay development and data delivery
- Cost effective discovery of any structural rearrangement throughout the genome, including inversions and translocations
- Sequence, location and orientation from a single assay
- High resolution screening of individual genes to the entire genome
From the de novo discovery of large rearrangements, to specific targets as small as 2kb, the versatility of dGH provides researchers and scientists with structural genomic insight at almost any level.
What is dGH?
KromaTiD’s directional Genomic Hybridization™ (dGH) technology combines bioinformatics driven design of unique single-stranded synthetic probes with strand-specific hybridization strategies, and is the only genomics approach capable of detecting DNA sequence, location and orientation in a single test.
With the ability to resolve very small inversions and translocations, dGH technology can be employed in both targeted and unbiased discovery studies, quickly providing data on new or variable rearrangements for your patient screening or target validation needs.
If a complete genetic profile is required, pair dGH with NGS on the same samples to build a comprehensive mutation profile.