dGH SCREEN™
Our genomic stability assays & chromatid paints provide
high-resolution data analysis.
Take Your Genomic Analysis to the Next Level
Remove the guesswork. Now you can see what’s going on in the rest of the genome. While sequencing provides valuable insights, dGH SCREEN takes genomic analysis to the next level. Whole genome de novo structural event attribution, one cell at a time, and gain the additional clarity necessary for groundbreaking discoveries.
dGH SCREEN karyogram of a triple-edited T cell displaying multiple inversions and a dicentric derivative composed of material from chromosomes 15 and 16.
What is dGH SCREEN?
The dGH SCREEN assay provides chromosome-level attribution of inter- and intra-chromosomal structural events, including inversions, translocations, aneuploidy (gain and loss), insertions, centromere abnormalities, and complex events across a sample. It combines dGH paints for all 24 human chromosomes.
- The assay is composed of unique sequence, high-density (HD) dGH chromosome paints in five color panels, allowing differentiation by size, shape, and centromere position.
- dGH probes spanning every chromosome provide unbiased coverage of the entire genome.
- Direct visualization of all types of structural rearrangements, including translocations, inversions, sister chromatid exchanges, and copy number variants.
- Chromosome size and color groupings enable identification of chromosomes involved in rearrangement events.
- Cell-by-cell data for complex or heterogeneous populations.
- Measure structural variants in chromosomes of interest for a targeted data set.