Direct, Definitive Genomics

single-cell innovative solutions for the discovery detection and quantification of genomic structural variations for gene and cell therapy researchers.
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Unidirectional dGH probes

Targeted tracking of transgenes as small as 2kb

Insertional copy number and distribution in heterogeneous cell populations

Detects structural variations in off target effects of CRISPR/Cas9

Unidirectional dGH probes

Unbiased, whole-genome assessment of all structural rearrangements

10x improvement in resolution over G-banding

3x the relative signal and resolution compared to BAC FISH

Repeat free

Detect targets as small as 2kb

Traditional G-banding and karyotyping analysis

Gold standard structural rearrangement detection

Applications

kromatid gene editing

Cellular Engineering

Monitoring Cellular Engineering Outcomes

On/Off Target Effects

Orthogonal Data for Sequencing

Variant Discovery

Genomic Stability Assessment

Oncology

Single-Cell Analysis

Complex Variation

Fusion Genes

Kromatid radiation biodosimetry

Radiation Biodosimetry

directional Genome Hybridization (dGH)

Structural Rearrangements

Inversions

Translocations

KromaTiD News

Essential, unique tools for discovery, detection and quantification of genomic structural variations