Genomic Integrity + Starting Material Analysis-1

High-Resolution Genomic Integrity Mapping

KROMASURE™ Screen is one of KROMATID’s flagship solutions which provides unbiased, high sensitivity karyotyping for chromosome mutation profiling and genomic integrity assessment. KROMASURE™ Screen is a whole genome molecular cytogenetic karyotyping method which provides strand-specific DNA orientation insights and unparalleled sensitivity for detecting chromosome mutations, including translocations, inversions and insertions as small as 20kb. A next-generation, hybridization-based technique that enables chromosome structural analysis with unmatched precision, ensuring researchers make confident, data-driven decisions in advancing cell and gene therapies.
 
For Starting Material Analysis our solution includes structural characterization of the genome and comparative reporting of cells during multiple passages to measure genomic stability over time. 
 
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Applications – When to Use Screen

  • Unbiased Genomic Analysis: Ensure a comprehensive, unbiased assessment of chromosomal integrity.
  • Detecting Hidden Changes: Identify all chromosomal variations with confidence, minimizing the risk of undetected abnormalities.
  • Regulatory Compliance: Obtain FDA-compliant data, including 20-cell G-Band analysis for IND submissions.
  • Independent Validation: Use as a secondary confirmation to strengthen research findings and enhance data reliability.
  • High-Sensitivity Integrity Mapping: Critical for cancer research and other applications where precise genomic integrity assessment is essential.

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Fluorescent Whole Genome Karyotyping

  • Single cell karyotype of hundreds of individual metaphase spreads.
  • Cytogenetic detection and characterization of low-prevalence events in heterogeneous cell populations.
  • Cross-sample analysis and comprehensive reporting.
  • Cell-based assay for orthogonal validation of structural variants flagged by NGS.
  • Has been included in IND filings.

Product Solutions Roadmap

Genomic Integrity Chart_v2-1

What Screen Detects

  • Translocation events 
  •  Chromosome Truncations
  •  Inter-chromosomal events
  •  Aneuploidy
  •  Sister Chromatid Exchange Events
  •  Sister chromatid fusions
  •  Centric Ring and/or Iso-Chromosome Formations
Screen can even detect complex events, including:
  • Chromosome Whole-Arm Deletion 
  • Scentromere Abnormalities
  • Whole-arm gain or multi-radial chromosomes
  • Chromatid-type and chromosome-type breaks
  • Chromothripsis/ fragmentation and the formation of ecDNA
  • Dicentric and other multi-centric chromosomes
  • Acentric chromosomes, and complex exchange event
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KROMASURE Complete Genomic Integrity Graphic
DGH Screen Data Sheet

KROMASURE™ Screen

KROMASURE™ Screen is one of KROMATID's flagship solutions. Offering high sensitivity karyotyping and genomic integrity assessment. Learn more about this solution!

 

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