KROMATID Blog

All HSCs Are Not Created Equal: The Importance of Testing Your Starting Material Genomic Integrity Starting Material Analysis HSC's Hematopoietic stem cells (HSCs) sit at the foundation of many cell and gene therapy programs. Whether used in autologous or allogeneic settings, ex vivo gene editing or viral transduction, HSCs are often treated as a standardized input—assumed to be equivalent as long as basic identity, viability, and purity criteria are met.