The original KromaTiD assay, dGH SCREEN™ was initially utilized by NASA to monitor the effects of ionizing deep space radiation in their astronauts.
Famously dubbed the “Twins Study”, NASA’s first foray into “omics” research (genome DNA sequencing, RNA sequencing, methylation/epigenetics, proteomics, metabolomics) utilized our dGH platform and dGH Chromatid paints. This represented a unique opportunity to develop personalized medicine approaches to measuring individual responses to spaceflight. dGH played an important and complementary role identifying genomic structural rearrangements associated with the radiation exposure from spaceflight.
Our dGH SCREEN™ platform is still being used by NASA to assess structural rearrangements in the genomes of their best and brightest. dGH SCREEN’s unique single stranded design allows researchers to visualize and quantify inversions as an inherently more stable biodismeter than dicentrics, which enables them to obtain data much longer after a radiation event. In addition to greater stability, inversions occur with lower background frequency than other symmetrical aberrations such as translocations, providing fewer false positives and more reliable data.
dGH SCREEN™ provides an unbiased, single cell, high-resolution whole-genome stability analysis. Provides detection of translocations, inversions, and complex rearrangements with a lower limit of detection of 5Kb, giving the researcher a true profile of structural heterogeneity throughout your edited cells populations. SCREEN provides an efficient measurement of stability of your clones and cell lines.