dGH SCREEN, the original KromaTiD assay, was initially utilized by NASA to monitor the effects of ionizing deep space radiation in their astronauts. Famously dubbed the “Twin’s Study” using our dGH platform and dGH Chromatid paints. This was NASA’s first foray into “omics” research (genome DNA sequencing, RNA sequencing, methylation/epigenetics, proteomics, metabolomics), and as such represented a unique opportunity to develop personalized medicine approaches to measuring individual responses to spaceflight. We played an important and complementary role by designing the dGH assays and validating the candidate structural rearrangements.
From 2015 to today our dGH SCREEN platform is still being used by NASA to assess structural rearrangements in the genomes of their best and brightest. dGH SCREEN’s unique single stranded design allows researchers to visualize and quantify inversions as an inherently more stable biodismeter than dicentrics, which enables them to obtain data much longer after a radiation event. In addition to greater stability, inversions occur with lower background frequency than other symmetrical aberrations such as translocations, providing fewer false positives and more reliable data.