Measuring DNA Damage.
DNA damage is a common consequence of exposure to various genotoxic agents, chemicals, and oxidative stress, not just radiation. Understanding the mechanisms of DNA damage and repair is essential for developing strategies to mitigate the adverse effects of genotoxic insults. Many model systems serve to further such research, such as rodents.
This image features the chromosomes of a mouse fibroblast used as part of a biodosimetry investigation. dGH tools can be applied in non-human settings as well. Based on synthetic oligonucleotides, custom dGH probes can be manufactured to target sequences in other published mammalian genomes. This includes rodents, larger mammals like dogs and cats, or commercial lines like CHO cells. As demonstrated in this image, the dGH system can successfully detect structural variants outside of the human genome setting.