KromaTiD Blog2023-03-22T10:28:23-06:00

KromaTiD’s Dark Lab Files: A Blog

Advancements and Challenges in CAR T-Cell Therapy for Myeloid Malignancies

Great strides have been made in the treatment of B-cell malignancies with Chimeric antigen receptor (CAR) T-cell therapies. Efforts have been less successful when applying the technology to myeloid malignancies. Research published this year focusing on AML showcases the challenges.1 Myeloid malignancies, characterized by [...]

March 22, 2024|Tags: , , |

CB-011: A Gene-Edited CAR-T Therapy Against Multiple Myeloma

Multiple myeloma (MM) is a complex blood cancer affecting plasma cells. Patients can experience bone damage and fractures, kidney failure resulting from protein buildup, anemia and more frequent infections, among other symptoms. Given the disease's serious impacts to quality and length of life, scientists [...]

March 15, 2024|Tags: , , |

Genomic Insights into Cancer from the 100,000 Genomes Cancer Program

The 100,000 Genomes Cancer Program is a UK government research initiative aimed at integrating genomic data with clinical information to gain insights into the molecular basis of cancer. It involves the sequencing of genomes from 100,000 cancer patients, encompassing a diverse range of cancer [...]

March 8, 2024|Tags: , , |

In Situ 3D Scaffold-Mediated T-Cell Transduction

Use of three-dimensional (3D) scaffolds in vivo to influence cell behavior is not a new concept. However, recently reported work innovatively applies the approach to the field of cancer immunotherapy1. The use of 3D scaffolds loaded with lentiviral vectors (LVs) to program host T-cells [...]

March 1, 2024|Tags: , , , , |

Natural Killer T (NKT) Cells in Cancer Immunotherapy

While T cells engineered with chimeric antigen receptors (CAR-T cells) have revolutionized the landscape of hematologic malignancy treatment, their efficacy against solid tumors remains limited. However, there is a promising alternative: Natural Killer T (NKT) cells. These innate-like T lymphocytes are unique contenders in [...]

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