TP53/CEP17 Pinpoint FISH™ Probe

Efficiently detect deletions and rearrangements in the TP53 gene with confidence.

Above Fig.: TP53/CEP17 Kit hybridization in control line GM12753 including close-up view.

Optimized TP53/CEP17 Probe: Elevating Precision with Exceptional Signal-to-Noise Performance.

Probe Target Location:
TP53, 17p13, Atto550
CEP17, 17q11.1-q11.2, 6-FAM

The probe mix consists of a TP53 probe that covers the whole TP53 gene and the control probe which targets the 17q11.1-q11.2 region. Detect the copy number of the LSI TP53 probe target located at 17p13 and of the 17q11.1-q11.2 locus.

FISH probes are designed with advanced bioformatics and manufactured from synthetic oligonucleotides for high signal-to-noise ratio. Discover the power of Pinpoint FISH™ for TP53 and CEP17 analysis and boost your confidence with KromaTiD probes.

Above Fig.: Multiplex hybridization in human control line GM12753. The TP53/CEP17 Pinpoint FISH™ Kit probes target TP53 (red) and the 17q11.1-q11.2 pericentric region (green), and the added subCEP probe (aqua) targets the 5q11.1-q11.2 pericentric region.

Multiplex Any Pinpoint FISH™ Probes for Unique Datasets.

Being able to freely combine probes targeting high-value cancer targets like TP53 allows researchers to ask unique experimental questions. If they rely on the pre-configured probe combinations a manufacturer chooses to sell, they may not be able to generate the exact data required. For example, some combinations of TP53 abnormalities and chromosome 5 abnormalities are associated with poor prognostic outlooks, relative to the detection of either one alone.

To assay whether a TP53 deletion and a whole-arm 5q deletion are present in the same cell, Pinpoint FISH probes can be run together, as in the image to the left. Other Pinpoint FISH probes users may add include custom probes, whole chromosome paints, subtelomere probes and more. Thanks to the bioinformatic screening process applied to all probe products KromaTiD designs, combined reactions reliably produce excellent performance. 

*For use in metaphase or interphase cells  fixed with 3:1 MeOH:Acetic acid.

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