Genomic Integrity Karyotyping Services

Preparation and analysis using Genomic Integrity G-Band Karyotyping for Genetic Stability.

Above Fig.: G-banded karyogram of a genomic integrity baseline wild type T cell sample for comparison with edited T cells.

Develop and Start a Study Plan for Genomic Integrity G-band Karyotyping as a QC Method for your Cell Lines to Support your Cell Therapies

G-Banding:  KromaTiD can perform an analysis of 100+ samples for Genomic Integrity using G-Band Karyotyping for quality control assessment of your Investigational New Drug (IND).

Karyotyping Reports: Comprehensive reports for each sample are prepared, summarizing the G-banding results and any identified chromosomal abnormalities.  Reports are provided for both the wild type and treated cells. Genomic Integrity Reports are provided of a side-by-side comparison of your cell samples for your genomic integrity assessment and IND submission.

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Reach out to KromaTiD to explore your Genomic Integrity G-Band Karyotyping QC requirements.

Above Fig.: G-banded karyogram of an edited T cell sample showing loss of one homolog each for chromosomes 19 and 22.

Distinguish between Origins of Genomic Abnormalities

Informed interpretation based on analysis of a matching number of edited cells becomes possible via a side-by-side comparison. Low-frequency aneuploidies, for example, are assessed for statistical significance to determine the variance from the baseline sample. All cell handling and editing processes can cause structural variants. By comparing data from loci proximal to edit sites it becomes possible to distinguish between different origins of genomic abnormalities, such as the editing process itself, culture expansion, random chance, or abnormalities which were pre-existing.

Above Fig.: Portion of sample genomic integrity report showing tallied abnormalities.

Genomic Integrity Data Reports

With all genomic integrity reports, KromaTiD summarizes all the information necessary to interpret results. This includes the numbers of abnormalities by type, comparing wild type and edited samples side-by-side for each category. Reports include overall karyotype outcome for each sample, as well as the karyotype designation for each cell. Reports include a glossary of all relevant cytogenetics terms and abbreviations.

Catalog Number
CYT-005 T-Cell Culture Development: Thaw, recovery, and harvest optimization $1,125
CYT-009 T-Cell Metaphase Prep and Harvest $1,125
CYT-006 IPSC Cell Culture Development: Thaw, recovery, and harvest optimization $1,250
CYT-010 IPSC Metaphase Prep and Harvest $1,250
CTY-007 Whole Blood Culture Development: Thaw, recovery, and harvest optimization $688
CYT-011 Whole Blood Metaphase Prep and Harvest $688
CYT-014 NK Cell Culture and Development $1,125
CYT-013 NK Cell Metaphase Prep and Harvest $1,125
CYT-002 20 cells/sample Assay Execution and Analysis $788
CYT-004 50 cells/sample Assay Execution and Analysis $1,640
CYT-012 100 cells/sample Assay Execution and Analysis $3,255
CYT-003 200 cells/sample Assay Execution and Analysis $5,250
CYT-020 G-Banding Genomic Integrity Report $1,600
CYT-021 Custom G-Band Report: Extended analysis beyond standard G-band report Inquire
CYT-022 Genomic Integrity G-Band Karyotyping Package: In depth G-Band analysis to monitor cell and gene therapy batch integrity Inquire
CYT-023 G-Banding Qualification Study: Customized services including, but not limited to, cell prep, assay execution, custom reporting, release spec guidance, study management Inquire