Discover rare chromosomal structural variants using dGH assays.
Biomarker discovery and target validation are pivotal in advancing our understanding of diseases and developing effective treatments. The use of dGH SCREEN, dGH DSCVR, and dGH in-Site is the ultimate trifecta of assays representing cutting-edge technologies that empower researchers to uncover rare chromosomal variants unseen with other methods.
directional Genomic Hybridization (dGH) is a unidirectional, in situ hybridization technique where single-stranded, fluorescently labeled DNA probes are hybridized to parental-strand only, metaphase spreads. This enables dGH to provide high-resolution identification and direct visualization of all manner of genomic structural variants including translocations, sister-chromatid exchanges, structural variations, rearrangements, and previously undetectable inversions.