
dGH in-Site™
Examine Edits One Cell at a Time
dGH in-Site™ gives researchers the ability to directly visualize and characterize rearrangements at their edit sites. Using synthetic oligo probes and repeat-free bioinformatic design, dGH in-Site is capable of tracking edit site translocations, inversions, copy number variants, viral integrations and other complex rearrangements with an ≈2kb resolution.
As an orthogonal analysis to PCR/sequencing techniques, dGH in-Site™ assays enable, through direct visualization, definitive measurement of the presence or absence of inserts. This includes genome-wide distribution and orientation of transgenes or inserted segments. When used in combination with our targeted probes and chromosome paints, dGH in-Site™ assays can provide quantitative, single cell on- vs. off-target outcomes of the delivery and editing process, and can be used to track the stability of the edited genome in both clonal isolates and non-clonal populations.
Concerns over a safe edit site? dGH in-Site™ allows researchers to examine their edits one cell at a time without having to worry about PCR biases or misrepresentative sequencing averages from heterogeneous cell populations. An orthogonal and complementary technique dGH in-Site™ to PCR/sequencing techniques helps provide the most comprehensive data available.
Ordering Information
Products |
List Price |
---|---|
Non-refundable set-up fee (when applicable) | Project Specific |
Assay, execution, imaging, and scoring (1 Probe) | $3,220/sample |
Assay, execution, imaging, and scoring: Additional Probes | $1,000/probe |
Custom Probes (Design and Verification) | $5,000/probe |
Standard Probe Production | $1,000/probe |
Culture Development | $500/sample |
Cell Culture + Harvest | $500/sample |