The Pinpoint FISH™ TP53/CEP17 probe kit is an oligonucleotide-based FISH assay. These probes are designed to provide a higher signal-to-noise ratio compared to BAC FISH probes. Delivering improved specificity and hybridization in standard FISH assays.
With KromaTiD’s probe kit you can easily detect mutations with variable breakpoints free of repetitive sequences, providing robust performance bright signals, and consistent hybridization quality without the need for Cot-1 DNA Blocking.
TP53, 17p13. Red
The probe mix consists of a 500kb TP53 probe, labeled in red, that covers the whole TP53 gene and the flanking regions. The probe mix also contains a control probe targeting the 17q11.1-q11.2 region labeled in green.
The Pinpoint FISH™ TP53/CEP 17 FISH Probe Kit is intended to detect the copy number of the LSI TP53 probe target located at 17p13 and of the 17q11.1-q11.2 locus. The approximately 500kb TP53 probe contains the complete TP53 gene and is located at 17p13. The CEP 17 probe is a control probe which hybridizes to the 17q11.1-q11.2 locus.
KromaTiD’s Pinpoint FISH™ TP53/CEP17 Kit is ideal for the following FISH applications:
- Screening of hematological and other cell suspension samples
- Testing of indications including, CLL, PLL, LPD and myeloma
Pinpoint FISH™ probes routinely detect targets smaller than BAC FISH probes. For labs that currently run FISH on hematological and other suspension cell samples, the TP53/CEP17 Assay Kit uses standard FISH consumables and standard FISH equipment. Probes have been tested in combination assays with BAC FISH probes and can work in the same assays.