The field of cytogenetics has enabled deep insights into the structure and behavior of chromosomes and the DNA from which they are built. Cytogenetics methods like G-Banding and Fluorescence In Situ Hybridization (FISH) enable researchers to identify segments of DNA for enumeration or analysis of position and structure. However, these methods are now considered “classical” or “legacy” cytogenetics techniques, and the progress of science which gave rise to them has certainly not stopped. Via webinar, scientists Susan Bailey and Christopher Tompkins discuss how directional Genomic Hybridization (dGH™) evolved from traditional FISH, granting easy access to invaluable new data on DNA damage, chromosomal structural variants and how the prevalence of those rearrangements can change over time.