Boosting CAR-T Cell Therapy with ICIs
Immune checkpoint inhibitors (ICIs) are a class of molecules that target specific biochemical pathways involved in regulating immune responses. These pathways, known as immune checkpoints, [...]
Avidity, Affinity, and B7H3 as a Cancer Cell Marker
Successful targeting of cell-surface tumor markers by various methods has made identification of such molecules a potentially high pay-off goal for the creation of new [...]
New Research Characterizes Optical Genome Mapping False-Negative Risk
Optical Genome Mapping (OGM) is a technology which employs microfluidics, image analysis, and high-resolution microscopy to detect structural variations (SVs). The process begins with the [...]
Advancements and Challenges in CAR T-Cell Therapy for Myeloid Malignancies
Great strides have been made in the treatment of B-cell malignancies with Chimeric antigen receptor (CAR) T-cell therapies. Efforts have been less successful when applying [...]
CB-011: A Gene-Edited CAR-T Therapy Against Multiple Myeloma
Multiple myeloma (MM) is a complex blood cancer affecting plasma cells. Patients can experience bone damage and fractures, kidney failure resulting from protein buildup, anemia [...]
Genomic Insights into Cancer from the 100,000 Genomes Cancer Program
The 100,000 Genomes Cancer Program is a UK government research initiative aimed at integrating genomic data with clinical information to gain insights into the molecular [...]
In Situ 3D Scaffold-Mediated T-Cell Transduction
Use of three-dimensional (3D) scaffolds in vivo to influence cell behavior is not a new concept. However, recently reported work innovatively applies the approach to [...]
Live on our YouTube our Latest Webinar: Combining Synthetic and Evolutionary Biology Reveals DNA Therapy to Combat Cancer Chemoresistance
https://www.youtube.com/watch?v=ACj85aO00hY&t=176s
Natural Killer T (NKT) Cells in Cancer Immunotherapy
While T cells engineered with chimeric antigen receptors (CAR-T cells) have revolutionized the landscape of hematologic malignancy treatment, their efficacy against solid tumors remains limited. [...]
Automating CAR-NK Cell Manufacturing
Acute myeloid leukemia (AML) is a neoplastic process characterized by its aggressive nature and limited treatment options. Too many AML patients are unable to achieve [...]