Boosting CAR-T Cell Therapy with ICIs
Immune checkpoint inhibitors (ICIs) are a class of molecules that target specific biochemical pathways involved in regulating immune responses. These pathways, known as immune checkpoints, [...]
Immune checkpoint inhibitors (ICIs) are a class of molecules that target specific biochemical pathways involved in regulating immune responses. These pathways, known as immune checkpoints, [...]
Successful targeting of cell-surface tumor markers by various methods has made identification of such molecules a potentially high pay-off goal for the creation of new [...]
Optical Genome Mapping (OGM) is a technology which employs microfluidics, image analysis, and high-resolution microscopy to detect structural variations (SVs). The process begins with the [...]
Great strides have been made in the treatment of B-cell malignancies with Chimeric antigen receptor (CAR) T-cell therapies. Efforts have been less successful when applying [...]
Multiple myeloma (MM) is a complex blood cancer affecting plasma cells. Patients can experience bone damage and fractures, kidney failure resulting from protein buildup, anemia [...]
The 100,000 Genomes Cancer Program is a UK government research initiative aimed at integrating genomic data with clinical information to gain insights into the molecular [...]
Use of three-dimensional (3D) scaffolds in vivo to influence cell behavior is not a new concept. However, recently reported work innovatively applies the approach to [...]
https://www.youtube.com/watch?v=ACj85aO00hY&t=176s
While T cells engineered with chimeric antigen receptors (CAR-T cells) have revolutionized the landscape of hematologic malignancy treatment, their efficacy against solid tumors remains limited. [...]
Acute myeloid leukemia (AML) is a neoplastic process characterized by its aggressive nature and limited treatment options. Too many AML patients are unable to achieve [...]