Adenine Base Editor mRNA Restores β-globin Functionality
Sickle cell disease (SCD) is a hereditary blood disorder caused by malformed β-globin protein in red blood cells. It has long been a target for [...]
Vertex, CRISPR and Bluebird Bio Receive FDA Approval for Two Gene Therapies for Sickle Cell
For Immediate Release: December 08, 2023 Today, the U.S. Food and Drug Administration approved two milestone treatments, Casgevy and Lyfgenia, representing the first cell-based gene [...]
Measuring the Mechanical Force of TCR-Antigen Interactions
T cells, a frontline element in our bodies’ defense against pathogenic invaders, rely on the T cell receptor (TCR) to recognize enemies. This cell surface [...]
KromaTiD and SeQure Dx Partnership Agreement Offers Comprehensive IND-Enabling Gene Editing Services
KromaTiD and SeQure Dx enter partnership agreement to offer comprehensive, IND-enabling gene editing services supporting cell and gene therapy research Longmont, CO. and Waltham, [...]
KOLF2.1J: A Potential iPSC Standard Cell Line
Induced pluripotent stem cells (iPSCs) hold great value in research because of their unique ability to differentiate into various cell types. These cells offer a [...]
Editing DNA: DSBs vs Nicking – Examining the Pros and Cons
Gene editing technologies have revolutionized the field of molecular biology, offering powerful tools to modify DNA with precision. Two primary categories of gene editing methodologies [...]
Method for Mitigating CRISPR-Cas9 Editing-Associated Genotoxicity
The advent of CRISPR-Cas9 marked a turning point in the realm of genetics and molecular biology. The technology made gene editing more accessible, efficient, and [...]
Clinical and Research Applications of Peripheral Blood
Whether it be for clinical or research studies, peripheral blood (PB) is one of the most accessible human sample types. It serves as a window [...]
Precise Spectral Partitioning in Fluorescence Microscopy
Fluorescence microscopy is a powerful tool used for many scientific and medical applications to gather data at the highest possible resolution. A vital part of [...]
Detecting Chromosomal Structural Variants
Human chromosomes are intricate and dynamic structures. Along the length of a chromosome’s DNA are regions encoding proteins, sequences regulating gene expression, pieces of viral [...]