KromaTiD’s Dark Lab Files: Plasmid Manufacturing for Applications – CAR-T Engineering Segment
A variety of DNA modification tools are relied upon for advanced gene and cell therapies (i.e. CAR-T cells) to continue to progress. These include [...]
KromaTiD’s Dark Lab Files: CAR-T Cell Manufacturing and Quality Control
Autologous CAR-T cell therapy is a type of adoptive cell therapy in which T-cells from a patient’s own immune system are modified in a laboratory [...]
KromaTiD’s Dark Lab Files: The Story Behind our dGH SCREEN Assay and Chromatid Paints
The original KromaTiD assay, dGH SCREEN™ was initially utilized by NASA to monitor the effects of ionizing deep space radiation in their astronauts. Famously dubbed [...]
KromaTiD’s Dark Lab Files: The Great Race to Cure Cancer – iPSC Segment
iPSC’s (induced Pluripotent Stem Cells) are an important cell for cancer studies. Human embryonic stem cells have two important properties; self-renewal (pluripotent) and an ability to [...]
KromaTiD’s Dark Lab Files: Happy National Cytotechnology Day!
Microscopic study of the cells in our bodies is what Cytotechnology is all about. Taking our cells, putting them on a slide and reading them [...]
KromaTiD’s Dark Lab Files: The Great Race to Cure Cancer – CAR-T Segment
As technologies evolve, therapies for cancer have advanced and more and more researchers are finding out how the science of our bodies make us ill [...]
KromaTiD’s Dark Lab Files : Cytogenetics a Little History Lesson
Cytogenetics has been a key part of biology since 1842, a Swiss botanist named Karl Nägeli had first discovered chromosomes in pollen. Many decades later [...]
KromaTiD’s Dark Lab Files: FDA Draft Guidelines for Human Gene Therapy Products Incorporating Human Genome Editing
Last month March 2022, the FDA released Draft guidelines for Human Gene Therapy Products Incorporating Human Genome Editing. This guideline is a Draft and as [...]
DNA Probes and their Importance in Oncology
DNA probes are simply oligonucleotides (short sequences of DNA) approximately 100-1000bp long, that are used to detect the presence of [...]
Structural Variations in Rare and Undiagnosed Diseases
First let’s define what a Structural Variation is. A structural variation (SV) is generally defined as a region of [...]