Rareservoir: A Powerful Genomic Tool for Rare Disease Research
Despite significant strides in genetic research, we lack a clear understanding of whether many rare diseases may have genetic origins, and of what those origins [...]
Unbiased Visualization of Structural Rearrangements
DNA double-strand breaks (DSBs) and potential misrepair events can result from the use of gene editing tools like CRISPR/Cas systems. These misrepairs are associated with [...]
New Genotoxicity Concerns in Nickase-Based Editing Systems
In the context of gene editing applications, genotoxicity may be defined as, “the property of an agent able to alter the genetic function within a [...]
KromaTiD Webinar | Combining Synthetic and Evolutionary Biology Reveals DNA Therapy to Combat Cancer Chemoresistance
Register below for the KromaTiD Webinar | Combining Synthetic and Evolutionary Biology Reveals DNA Therapy to Combat Cancer Chemoresistance Drug resistance is still an ongoing [...]
The Longer-Term Effects of CAR-T Therapy
CAR T cell therapies have achieved substantial improvements in the prognoses of patients fighting advanced hematological malignancies, demonstrating robust efficacy in inducing durable remissions. While [...]
Mast Cells and Dendritic Cells as Cellular Immune Checkpoints
Solid tumors, with their intricate immune microenvironment, pose a formidable challenge to immunotherapy. Within this complex landscape, mast cells (MCs) and dendritic cells (DCs) emerge [...]
Pairing Immunotherapies: CAR-T and NK Cells
While immune checkpoint blockade therapies targeting T cells have shown promise, limitations arise in cases of tumor escape mechanisms, including HLA-I downregulation. Loss of HLA-I [...]
Natural Killer Cell Immunotherapy: Considerations and Opportunities
Cancer immunotherapy has witnessed remarkable advances in recent years, with much of the focus being on CAR-T cells. However, a great deal of research has [...]
CAR T Cells: Beyond Oncology
Chimeric Antigen Receptor (CAR) T cells are the protagonist in the evolving story of adoptive immunotherapy research. The villain in the story is almost always [...]
Adenine Base Editor mRNA Restores β-globin Functionality
Sickle cell disease (SCD) is a hereditary blood disorder caused by malformed β-globin protein in red blood cells. It has long been a target for [...]