Method for Mitigating CRISPR-Cas9 Editing-Associated Genotoxicity
The advent of CRISPR-Cas9 marked a turning point in the realm of genetics and molecular biology. The technology made gene editing more accessible, efficient, and [...]
The advent of CRISPR-Cas9 marked a turning point in the realm of genetics and molecular biology. The technology made gene editing more accessible, efficient, and [...]
CAR-T cells, or chimeric antigen receptor T cells, hold great potential for the treatment of cancer and other diseases. Although several CAR-T therapies have received [...]
Chimeric antigen receptor (CAR) constructs are purpose-built transmembrane proteins artificially added to immune cells, principally T cells, to enhance their ability to find and fight [...]
The design and manufacture of chimeric antigen receptor (CAR) T cells is fraught with complex hurdles. Some of these are encountered during production while others [...]
The pace at which autologous CAR-T cells can be manufactured has been an obstacle for this very powerful technology from the start. Producing a cutting-edge [...]
Cellular adoptive immunotherapies, such as CAR-T cells, are among the most effective tools in modern medicine’s toolbox for fighting cancer, yet tumor cells are nothing [...]
A variety of DNA modification tools are relied upon for advanced gene and cell therapies (i.e. CAR-T cells) to continue to progress. These include [...]
Autologous CAR-T cell therapy is a type of adoptive cell therapy in which T-cells from a patient’s own immune system are modified in a laboratory [...]
As technologies evolve, therapies for cancer have advanced and more and more researchers are finding out how the science of our bodies make us ill [...]